ASSESSING PROBIOTIC YOGURT SUPPLEMENTATION ON METABOLIC INFLAMMATION IN SEDENTARY ADULTS
Keywords:
Adult, Dietary Supplements, Inflammation, Lipid Metabolism, Probiotics, Randomized Controlled Trial, Sedentary Lifestyle, YogurtAbstract
Background: Sedentary lifestyles are increasingly recognized as contributors to low-grade systemic inflammation and dysregulated lipid metabolism, predisposing individuals to metabolic disorders. Probiotics, particularly when administered through fermented foods such as yogurt, have demonstrated potential in modulating inflammatory processes and lipid profiles by improving gut microbiota composition and immune regulation.
Objective: To examine whether daily supplementation with probiotic-enriched yogurt reduces inflammatory markers and improves lipid profiles compared to plain yogurt among sedentary adults.
Methods: This randomized controlled trial enrolled 120 sedentary adults from South Punjab, who were equally allocated to either a probiotic yogurt group or a plain yogurt group. Over a twelve-week period, each participant consumed 200 grams of their assigned yogurt daily. Baseline and post-intervention blood samples were analyzed to determine serum concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. Changes within and between the groups were evaluated using paired and independent t-tests, with statistical significance defined as .
Results: Compared to the control group, the probiotic yogurt group showed statistically significant reductions in hs-CRP () and IL-6 (), as well as notable favorable changes in LDL () and HDL () levels (). No adverse effects were observed, and participant compliance was greater than 90%.
Conclusion: Probiotic-enriched yogurt effectively attenuated metabolic inflammation and improved lipid regulation among sedentary adults. Regular consumption may serve as a practical dietary strategy to mitigate early metabolic risks associated with physical inactivity.
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Copyright (c) 2025 Ayesha Ashraf, Abdul Rehman Sarfraz, Hina Maqbool (Author)
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